N-Acylation in combinatorial chemistry

Combinatorial chemistry

Combinatorial chemistry, which did not even exist fifteen years ago, is a new subfield of chemistry that is starting to provide insights into molecular interactions, biochemical catalysis and drug development. Instead of finding and testing naturally existing compounds for useful activity, the basic aim of combinatorial chemistry studies is to create vast numbers of new, synthetic compounds and...

Combinatorial chemistry.

Encoding strategies in combinatorial chemistry.

To Pasteur’s famous dictum, ‘‘Chance favors the prepared mind,’’ could arguably be added the corollary, ‘‘As the number of chances increases, so increases the effect of favor.’’ It is nearly a truism that a great many important discoveries in chemistry originated not from careful design, but from astute observations of unintended experiments. Suppose, then, that creativity were applied to the t...

Concepts of Combinatorial Chemistry and Combinatorial Technologies

Combinatorial Chemistry and Combinatorial Technology (CC/CT) are a new interdisciplinary field joining computerassisted combinatorial chemistry with automated parallel synthesis of chemical ìlibrariesî followed by automated screening. The main purpose of computer assisted combinatorial chemistry is to generate thousands structurally diverse compounds as libraries, maximising their diversity, wh...

Microfluidic Device for Combinatorial Chemistry

This work presents a microfluidic device that has the unique capability of automating combinatorial processes such as protein refolding and bioconjugate synthesis. Conventionally, these processes are done by hand-pipetting or using robotic systems. The microfluidic approach offers the advantages of automation, cost-effectiveness, compatibility with optical detection, and a million-fold reductio...